Complete atrioventricular block after percutaneous device closure of perimembranous ventricular septal defect: A single-center experience on 1046 cases

Heart Rhythm. 2015 Oct;12(10):2132-40. doi: 10.1016/j.hrthm.2015.05.014. Epub 2015 May 14.

Abstract

Background: Complete atrioventricular block (cAVB) has been deemed a rare complication after transcatheter closure for ventricular septal defect (VSD). However, this serious event appears to be underrecognized and is worth being investigated further.

Objectives: To determine the incidence and predisposing factors of cAVB associated with closure of VSD using a modified double-disk occluder (MDO).

Methods: From December 21, 2001 to December 31, 2014, 1046 patients with perimembranous ventricular septal defect underwent percutaneous closure using the MDO. Electrocardiography was evaluated before the procedure, within 1 week after the procedure, and then at 1, 3, 6, and 12 months and every year thereafter. Other baseline and procedural parameters were also evaluated and a comparison between patients requiring pacemakers and those not suffering from cAVB was done.

Results: cAVB occurred in 17 patients (1.63%) after the procedure. Of the 17 patients, 8 underwent permanent pacemaker (PPM) implantation. The cAVB occurred within 30 days after the procedure in 14 patients and after 1 year in 3 patients. In comparison patients aged ≤18 years, patients aged >18 years were more prone to cAVB (P = .025). Logistic regression revealed no significant parameter to predict later requirement for PPM.

Conclusions: The incidence of cAVB after transcatheter closure of VSD was acceptable, as part of the cAVB population recovered after administration of corticosteroid and application of a temporary pacemaker. Late cAVB (>1 year) appears to make it more difficult to restore normal conduction block. Because of the recurrence of cAVB, life-long follow-up with periodic electrocardiography examination may be mandatory.

Keywords: Complete atrioventricular block; Complication; Percutaneous; Perimembranous ventricular septal defect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Atrioventricular Block / diagnosis
  • Atrioventricular Block / etiology*
  • Atrioventricular Block / physiopathology
  • Cardiac Catheterization / adverse effects
  • Cardiac Catheterization / methods*
  • Cardiac Surgical Procedures / adverse effects*
  • Cardiac Surgical Procedures / instrumentation
  • Child
  • Child, Preschool
  • Echocardiography
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Heart Septal Defects, Ventricular / surgery*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Prosthesis Failure
  • Retrospective Studies
  • Septal Occluder Device / adverse effects*
  • Time Factors
  • Treatment Outcome
  • Young Adult