Abstract
Herein, we report the facile preparation of cell-targeted platinum nanoparticles (PtNPs), through the design of peptides that, as a single molecule added in small concentration during the synthesis, control the size of PtNP clusters during their growth, stabilise the PtNPs in aqueous suspension and enable the functionalisation of the PtNPs with a versatile range of cell-targeting ligands. Water-soluble PtNPs targeted respectively at blood group antigens and at integrin receptors are demonstrated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells / drug effects
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Animals
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Biochemistry / methods*
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Blood Group Antigens / metabolism
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Concanavalin A / chemistry
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Erythrocytes / drug effects
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Erythrocytes / metabolism
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Humans
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Integrin alphaVbeta3 / metabolism
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Ligands
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / ultrastructure
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Mice
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Microscopy, Electron, Transmission
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Peptides / chemical synthesis
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Peptides / chemistry
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Platinum / chemistry*
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Platinum / pharmacology
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Rats
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Solubility
Substances
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Blood Group Antigens
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Integrin alphaVbeta3
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Ligands
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Peptides
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Concanavalin A
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Platinum