Proteasome inhibitors block Ikaros degradation by lenalidomide in multiple myeloma

Haematologica. 2015 Aug;100(8):e315-7. doi: 10.3324/haematol.2015.124297. Epub 2015 May 14.
No abstract available

Keywords: IKZF1 depletion; IMiDs; myeloma.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Ikaros Transcription Factor / metabolism*
  • Immunologic Factors / pharmacology*
  • Lenalidomide
  • Multiple Myeloma / genetics
  • Multiple Myeloma / metabolism*
  • Proteasome Inhibitors / pharmacology*
  • Proteolysis / drug effects
  • Thalidomide / analogs & derivatives*
  • Thalidomide / pharmacology

Substances

  • Immunologic Factors
  • Proteasome Inhibitors
  • Ikaros Transcription Factor
  • Thalidomide
  • Lenalidomide