Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp. KcF6

J Antibiot (Tokyo). 2015 Oct;68(10):653-6. doi: 10.1038/ja.2015.46. Epub 2015 May 13.

Authors

Zhiran Ju^{1

2}, Xiuping Lin¹, Xin Lu³, Zhengchao Tu³, Junfeng Wang¹, Kumaravel Kaliyaperumal¹, Juan Liu¹, Yongqi Tian¹, Shihai Xu², Yonghong Liu¹

Affiliations

¹ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
² Department of Chemistry, Jinan University, Guangzhou, China.
³ Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

PMID: 25966851
DOI: 10.1038/ja.2015.46

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology
Ascomycota / chemistry*
Cell Line, Tumor
Coumarins / chemistry
Coumarins / isolation & purification
Coumarins / pharmacology*
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / isolation & purification
Cyclooxygenase 2 Inhibitors / pharmacology*
Fermentation
Fruit / microbiology
Humans
Isocoumarins
Magnetic Resonance Spectroscopy
Rhizophoraceae / microbiology*
X-Ray Diffraction

Substances

Antibiotics, Antineoplastic
Coumarins
Cyclooxygenase 2 Inhibitors
Isocoumarins
botryoisocoumarin A