Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma

Oncotarget. 2015 Jun 10;6(16):14537-44. doi: 10.18632/oncotarget.3994.

Abstract

Background: Hypoxia is a key driver for infiltrative growth in experimental gliomas. It has remained elusive whether tumor hypoxia in glioblastoma patients contributes to distant or diffuse recurrences. We therefore investigated the influence of perioperative cerebral ischemia on patterns of progression in glioblastoma patients.

Methods: We retrospectively screened MRI scans of 245 patients with newly diagnosed glioblastoma undergoing resection for perioperative ischemia near the resection cavity. 46 showed relevant ischemia nearby the resection cavity. A control cohort without perioperative ischemia was generated by a 1:1 matching using an algorithm based on gender, age and adjuvant treatment. Both cohorts were analyzed for patterns of progression by a blinded neuroradiologist.

Results: The percentage of diffuse or distant recurrences at first relapse was significantly higher in the cohort with perioperative ischemia (61.1%) compared to the control cohort (19.4%). The results of the control cohort matched well with historical data. The change in patterns of progression was not associated with a difference in survival.

Conclusions: This study reveals an unrecognized association of perioperative cerebral ischemia with distant or diffuse recurrence in glioblastoma. It is the first clinical study supporting the concept that hypoxia is a key driver of infiltrative tumor growth in glioblastoma patients.

Keywords: MRI; glioblastoma; hypoxia; patterns of progression; perioperative ischemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain Ischemia
  • Brain Neoplasms / complications*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / pathology
  • Cell Hypoxia / physiology*
  • Cohort Studies
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Glioblastoma / complications*
  • Glioblastoma / mortality
  • Glioblastoma / pathology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Perioperative Period
  • Retrospective Studies
  • Survival Analysis