Convert and conquer: the strategy of chronic myelogenous leukemic cells

Cancer Cell. 2015 May 11;27(5):611-3. doi: 10.1016/j.ccell.2015.04.012.

Abstract

Emerging evidence is contributing to explain how leukemias disrupt normal blood cell production. In this issue of Cancer Cell, Welner and colleagues show that, during the development of chronic myeloid leukemia, mutated cells transform normal hematopoietic progenitors into "leukemic like" cells through IL-6 secretion, proposing a new cellular target.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cytokines / antagonists & inhibitors*
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*

Substances

  • Cytokines