Synthetic anion transporters that bear a terminal ethynyl group

Chem Commun (Camb). 2015 Jun 7;51(45):9339-42. doi: 10.1039/c5cc01903f.

Abstract

Cl(-) transporters that bear a terminal ethynyl group were synthesized; they consist of non-pyrrolic hydrogen bond motifs such as phenolic OH, amide NH, and triazole CH. The ethynyl group of these non-pyrrolic analogs plays an important role in chloride efflux and they exhibit no significant cytotoxic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylene / analogs & derivatives*
  • Acetylene / chemistry
  • Ion Transport
  • Models, Biological*
  • Molecular Structure
  • Organic Anion Transporters / chemical synthesis
  • Organic Anion Transporters / chemistry

Substances

  • Organic Anion Transporters
  • phenylacetylene
  • Acetylene