Regulating transcription traffic around DSBs

Brian S Plosky

doi:10.1016/j.molcel.2015.04.029

Regulating transcription traffic around DSBs

Mol Cell. 2015 May 7;58(3):391-2. doi: 10.1016/j.molcel.2015.04.029.

Author

Brian S Plosky¹

Affiliation

¹ Molecular Cell, Cell Press, 600 Technology Square, 5(th) Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.

PMID: 25957804
DOI: 10.1016/j.molcel.2015.04.029

Abstract

If a double-strand break (DSB) occurs and either a DNA polymerase or RNA polymerase is coming along, how do we save the train? In this issue of Molecular Cell, Ui et al. (2015) describe a connection between an elongation factor and a repressive complex to prevent transcription in proximity to a DSB.

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MeSH terms

Ataxia Telangiectasia Mutated Proteins / metabolism*
DNA Repair*
Humans
Neoplasm Proteins / metabolism*
Nuclear Proteins / metabolism*
Polycomb Repressive Complex 1 / metabolism*
Transcription Factors / metabolism*

Substances

Neoplasm Proteins
Nuclear Proteins
Transcription Factors
Polycomb Repressive Complex 1
Ataxia Telangiectasia Mutated Proteins