A rare cause of nephrotic syndrome in autosomal-dominant polycystic kidney disease

Ray K Wan; David Kipgen; Scott Morris; R Stuart C Rodger

doi:10.1093/ndtplus/sfn197

A rare cause of nephrotic syndrome in autosomal-dominant polycystic kidney disease

NDT Plus. 2009 Apr;2(2):136-8. doi: 10.1093/ndtplus/sfn197. Epub 2008 Dec 25.

Authors

Ray K Wan¹, David Kipgen², Scott Morris³, R Stuart C Rodger¹

Affiliations

¹ Renal Unit.
² Pathology Department, Western Infirmary General.
³ Renal Unit, Glasgow Royal Infirmary, Glasgow , UK.

Abstract

We report the case of a 49-year-old lady who presented with hypertension, breathlessness and malaise. She was thrombocytopenic, with polycystic kidneys on imaging, and was found to have nephrotic syndrome. Serological results were consistent with systemic lupus erythematosus (SLE) and a renal biopsy confirmed WHO class V lupus nephritis. This is the first reported case of nephrotic syndrome due to lupus nephritis in a patient with autosomal dominant polycystic kidney disease (ADPKD) and underlines the importance of renal biopsy in patients with ADPKD and nephrotic range proteinuria.

Keywords: lupus; nephrotic syndrome; polycystic.

Publication types

Case Reports