GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutrophil aggregates

Thromb Haemost. 2015 Aug;114(2):434-7. doi: 10.1160/TH14-12-1060. Epub 2015 May 7.

Authors

J M Herter, F Kraft, H Van Aken, M Meersch, A Zarbock, J Rossaint¹

Affiliation

¹ Jan Rossaint, MD, University of Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany, Tel.: +49 251 8347252, Fax: +49 251 88704, E-mail: rossaint@uni-muenster.de.

PMID: 25948320
DOI: 10.1160/TH14-12-1060

No abstract available

MeSH terms

Animals
Blood Platelets / drug effects
Blood Platelets / physiology
Capillary Permeability
Cell Adhesion
Chemotaxis, Leukocyte / drug effects
Drug Evaluation, Preclinical
Extracellular Traps / drug effects
Growth Differentiation Factor 15 / deficiency
Growth Differentiation Factor 15 / genetics
Growth Differentiation Factor 15 / pharmacology*
Growth Differentiation Factor 15 / therapeutic use
Lung / metabolism
Mice
Mice, Inbred C57BL
Muscle, Skeletal / pathology
Neutrophils / drug effects
Neutrophils / physiology*
Platelet Adhesiveness / drug effects
Platelet Adhesiveness / physiology*
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
Platelet Transfusion
Pulmonary Edema / physiopathology
Pulmonary Edema / prevention & control
Pulmonary Gas Exchange
RNA, Messenger / biosynthesis
RNA, Messenger / genetics
Radiation Chimera
Tirofiban
Tyrosine / analogs & derivatives
Tyrosine / pharmacology
Tyrosine / therapeutic use
Ventilator-Induced Lung Injury / genetics
Ventilator-Induced Lung Injury / physiopathology
Ventilator-Induced Lung Injury / prevention & control*

Substances

Growth Differentiation Factor 15
Platelet Glycoprotein GPIIb-IIIa Complex
RNA, Messenger
Tyrosine
Tirofiban