Mitotic spindle orientation: semaphorin-plexin signaling flags the way

Patrick O Humbert; Nathan J Gödde

doi:10.1016/j.devcel.2015.04.012

Mitotic spindle orientation: semaphorin-plexin signaling flags the way

Dev Cell. 2015 May 4;33(3):243-4. doi: 10.1016/j.devcel.2015.04.012.

Authors

Patrick O Humbert¹, Nathan J Gödde²

Affiliations

¹ Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia; Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: patrick.humbert@petermac.org.
² Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.

PMID: 25942620
DOI: 10.1016/j.devcel.2015.04.012

Abstract

The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney development and repair.

Publication types

Comment

MeSH terms

Animals
Cell Adhesion Molecules / metabolism*
Cell Division / physiology*
Kidney / metabolism*
Male
Morphogenesis / physiology*
Nerve Tissue Proteins / metabolism*
Semaphorins / metabolism*
Signal Transduction*
Spindle Apparatus / metabolism*

Substances

Cell Adhesion Molecules
Nerve Tissue Proteins
Semaphorins