Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity

Dawid Lewandowski; Marta Lewandowska; Piotr Ruszkowski; Anita Pińska; Grzegorz Schroeder

doi:10.1371/journal.pone.0126251

Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity

PLoS One. 2015 May 5;10(5):e0126251. doi: 10.1371/journal.pone.0126251. eCollection 2015.

Authors

Dawid Lewandowski¹, Marta Lewandowska¹, Piotr Ruszkowski², Anita Pińska², Grzegorz Schroeder¹

Affiliations

¹ Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
² Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.

Abstract

Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / administration & dosage
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line
Cell Proliferation / drug effects
Cell Survival / drug effects
Folic Acid / administration & dosage
HeLa Cells
Humans
Molecular Structure
Porosity
Silicon Dioxide*
Zidovudine / analogs & derivatives*
Zidovudine / chemistry
Zidovudine / pharmacology

Substances

Antineoplastic Agents
SBA-15
Zidovudine
Silicon Dioxide
Folic Acid

Grants and funding

Funding for this work came from the institution Narodowe Centrum Nauki (PL), www.ncn.gov.pl/, grant number: 2011/03/B/ST5/01573. The funding was received by author GS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.