Intraperitoneal oxidative stress as an oncolytic immunomodulator?

Oncoimmunology. 2014 Dec 13;3(9):e955347. doi: 10.4161/21624011.2014.955347. eCollection 2014 Oct.

Abstract

Intraperitoneal oxidative stress effectively converts the immune response against the papillomavirus-associated rabbit VX2 carcinoma from tumor permissive to tumoricidal and leads to a sustainable oncolytic immune response that can be adoptively transferred.

Keywords: VX2; cancer therapy; head and neck cancer; oxidative stress; papillomavirus; tumor animal model.