Abstract
In this study, multivalent carrier-free aptamer-RNA based fluorescent probes (CF-probes) were designed as a simpler, more reliable, timesaving strategy for cellular miRNA detection. CF-probes spontaneously delivered into cells without the need for additional carriers and visualized target microRNA-34a specifically.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aptamers, Nucleotide / chemistry*
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Cell Line, Tumor
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Electrophoresis, Polyacrylamide Gel
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Flow Cytometry
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Fluorescent Dyes / chemistry
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Humans
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MCF-7 Cells
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MicroRNAs / analysis*
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MicroRNAs / blood
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MicroRNAs / urine
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Microscopy, Confocal
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Mucin-1 / metabolism*
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Oligonucleotides / chemistry
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Spectrometry, Fluorescence
Substances
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Aptamers, Nucleotide
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Fluorescent Dyes
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MicroRNAs
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Mucin-1
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Oligonucleotides
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locked nucleic acid