Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA

Dokl Biochem Biophys. 2015:461:106-9. doi: 10.1134/S1607672915020118. Epub 2015 May 5.

Authors

I E Kasheverov¹, D S Kudryavtsev, I A Ivanov, M N Zhmak, A O Chugunov, V M Tabakmakher, E A Zelepuga, R G Efremov, V I Tsetlin

Affiliation

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia, shak_ever@yahoo.com.

PMID: 25937226
DOI: 10.1134/S1607672915020118

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholine / pharmacology
Algorithms*
Amino Acid Sequence
Animals
Aplysia
Conotoxins / chemistry*
Conotoxins / genetics
Dose-Response Relationship, Drug
Drug Design*
Humans
Ligands
Lymnaea
Membrane Potentials / drug effects
Membrane Potentials / physiology
Models, Molecular
Molecular Sequence Data
Nicotinic Agonists / pharmacology
Nicotinic Antagonists / chemistry*
Nicotinic Antagonists / pharmacology
Oocytes
Xenopus laevis
alpha7 Nicotinic Acetylcholine Receptor / agonists
alpha7 Nicotinic Acetylcholine Receptor / antagonists & inhibitors
alpha7 Nicotinic Acetylcholine Receptor / chemistry*
alpha7 Nicotinic Acetylcholine Receptor / metabolism

Substances

Conotoxins
Ligands
Nicotinic Agonists
Nicotinic Antagonists
alpha-conotoxin PnIA
alpha7 Nicotinic Acetylcholine Receptor
Acetylcholine