Preliminary evaluation of β3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese Zucker rat

Nucl Med Biol. 2015 Aug;42(8):691-4. doi: 10.1016/j.nucmedbio.2015.04.003. Epub 2015 Apr 16.

Abstract

Background: We have investigated β3-adrenoceptor agonist mediated brown adipose tissue (BAT) activation using (18)F-FDG PET/CT in Zucker lean (ZL) and obese (ZF) rats.

Methods: (18)F-FDG was injected into ZL and ZF rats pretreated with saline or agonist CL316,243 for scans. (18)F-FDG metabolic activity was computed as standard uptake values.

Results: CL316,243 in ZL activated BAT up to 4-fold compared to saline, while ZF BAT was only up by 2 fold. The decreased activation was consistent with lower β3-adrenoceptor levels in ZF rats.

Conclusions: The genetically modified ZL and ZF rats may provide a useful rat model to evaluate the significance of β3-adrenoceptor agonist-induced BAT activation in obesity.

Keywords: (18)F-FDG; CL316,243; Obesity; PET/CT; β3-Adrenoceptor agonist.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipose Tissue, Brown / diagnostic imaging*
  • Adipose Tissue, Brown / metabolism*
  • Adrenergic beta-3 Receptor Agonists / pharmacology*
  • Animals
  • Dioxoles / pharmacology*
  • Fluorine Radioisotopes / pharmacokinetics
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Isotope Labeling
  • Male
  • Metabolic Clearance Rate
  • Obesity / genetics
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacokinetics*
  • Rats
  • Rats, Zucker
  • Receptors, Adrenergic, beta-3 / metabolism
  • Thinness / genetics
  • Tissue Distribution

Substances

  • Adrenergic beta-3 Receptor Agonists
  • Dioxoles
  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Adrenergic, beta-3
  • Fluorodeoxyglucose F18
  • disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate