NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

Physiology (Bethesda). 2015 May;30(3):241-50. doi: 10.1152/physiol.00025.2014.

Abstract

The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology
  • Bacteria / metabolism*
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism*
  • Bacterial Infections / microbiology
  • Bacterial Translocation*
  • Gastroenteritis / immunology
  • Gastroenteritis / metabolism*
  • Gastroenteritis / microbiology
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Mucosal
  • Inflammasomes / immunology
  • Inflammasomes / metabolism
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / metabolism*
  • Intestinal Mucosa / microbiology
  • Nod Signaling Adaptor Proteins / immunology
  • Nod Signaling Adaptor Proteins / metabolism*
  • Permeability
  • Signal Transduction*

Substances

  • Inflammasomes
  • Nod Signaling Adaptor Proteins