Brugada Syndrome (BrS) is an inherited channelopathy causing sodium channel dysfunction in cardiac myocyte. These patients are prone to develop Ventricular Fibrillation (VF) or polymorphic Ventricular Tachycardia (VT). Next to coronary artery disease and cardiomyopathies, BrS is an important cause of sudden cardiac death. We report here a case of 22 year unmarried female with "unexplained" cardiac arrest without prior history of syncope and family history of sudden cardiac death. She was resuscitated out of hospital in some local dispensary in rural settings and after prolonged hypoxia with its neurological sequelae, she eventually died. BrS should be considered in differentials of unexplained cardiac arrest even in patients without family history of sudden cardiac death. First episode of VT/VF in BrS patients can be life threatening. Only prompt cardioversion / defibrillation can save life. We have suggested some measures to identify patients of BrS.