Recent advance in the structural analysis of HIV-1 envelope protein

Sci China Life Sci. 2015 May;58(5):420-4. doi: 10.1007/s11427-015-4852-1. Epub 2015 Apr 29.

Abstract

Human immunodeficiency virus type I (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in resourceful countries. Long-awaited anti-HIV-1 vaccine is still not with us yet; however, great progress in structural analyses of the envelope protein of HIV-1 in recent years starts to shed light on rational intervention targeted at the envelope protein, as will be reviewed in this article.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / immunology
  • Antibodies, Neutralizing / immunology
  • HIV Antibodies / immunology
  • HIV-1 / chemistry*
  • HIV-1 / genetics
  • HIV-1 / immunology
  • Host-Pathogen Interactions / immunology
  • Humans
  • Membrane Fusion
  • Models, Molecular
  • Mutation
  • Protein Conformation
  • env Gene Products, Human Immunodeficiency Virus / chemistry*
  • env Gene Products, Human Immunodeficiency Virus / genetics

Substances

  • AIDS Vaccines
  • Antibodies, Neutralizing
  • HIV Antibodies
  • env Gene Products, Human Immunodeficiency Virus