Three new iridoids from leaves of Cornus officinalis

J Asian Nat Prod Res. 2015;17(8):788-92. doi: 10.1080/10286020.2015.1026809. Epub 2015 Apr 28.

Abstract

Three new iridoids, cornifins A-C (1-3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC50 value of 29.1 μM.

Keywords: Cornaceae; Cornus officinalis; cornifins A–C; iridoids; structure and cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cornus / chemistry*
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • Iridoids / chemistry
  • Iridoids / isolation & purification*
  • Iridoids / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Iridoids
  • cornifin A iridoid
  • cornifin B iridoid
  • cornifin C iridoid