Effect of long-term pulsed electromagnetic field exposure on hepatic and immunologic functions of rats

Wien Klin Wochenschr. 2015 Dec;127(23-24):959-62. doi: 10.1007/s00508-015-0732-8. Epub 2015 Apr 25.

Abstract

Background: In this report, the effects of long-term pulsed electromagnetic field (PEMF) exposure on hepatic and immunologic functions were examined.

Methods: Male rats were randomly divided into four groups: a control group and three experimental groups exposed to a 50-Hz PEMF at 5, 10, or 20 mT for 10 weeks.

Results: Compared with the control group, activities of serum alanine aminotransferase and aspartate aminotransferase and concentrations of serum, liver, and spleen Metabolism of lipid peroxidation (MDA) in the 10- and 20-mT PEMF groups were significantly increased. The activities of Glutathione peroxidase (GSH-Px) and Superoxide Dismutase (SOD) in the serum, liver, and spleen and concentrations of serum immunoglobulins were significantly decreased.

Conclusion: These results demonstrate that long-term exposure to PEMF can lead to oxidative damage of the liver and spleen.

Keywords: Immune system; Liver; Pulsed electromagnetic fields; Rat; Spleen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption, Radiation
  • Animals
  • Cytokines / immunology
  • Dose-Response Relationship, Radiation
  • Electromagnetic Fields*
  • Environmental Exposure
  • Immunity, Innate / immunology*
  • Immunity, Innate / radiation effects
  • Liver / immunology*
  • Liver / radiation effects
  • Longitudinal Studies
  • Male
  • Oxidative Stress / immunology*
  • Oxidative Stress / radiation effects
  • Radiation Dosage
  • Rats
  • Rats, Wistar
  • Spleen / immunology*
  • Spleen / radiation effects
  • Whole-Body Irradiation / methods

Substances

  • Cytokines