Abstract
We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloidogenic Proteins / chemistry*
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Amyloidogenic Proteins / pharmacology*
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Animals
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Apoptosis / drug effects
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Cell Line, Transformed
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Cytosol / metabolism
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DNA-Binding Proteins / chemistry*
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Fluorescence
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Fluorescent Dyes / chemistry
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Frontotemporal Lobar Degeneration
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Humans
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Molecular Structure
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Protein Aggregates / drug effects*
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Protein Aggregation, Pathological / chemically induced*
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Rats
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Spectrometry, Fluorescence
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Time Factors
Substances
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Amyloidogenic Proteins
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DNA-Binding Proteins
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Fluorescent Dyes
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Protein Aggregates
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TARDBP protein, human