Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages

Dorothy P Schafer; Beth Stevens

doi:10.1016/j.immuni.2015.04.002

Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages

Immunity. 2015 Apr 21;42(4):600-2. doi: 10.1016/j.immuni.2015.04.002.

Authors

Dorothy P Schafer¹, Beth Stevens²

Affiliations

¹ Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: dorothy.schafer@umassmed.edu.
² Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.

PMID: 25902477
DOI: 10.1016/j.immuni.2015.04.002

Abstract

Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.

Publication types

Comment

MeSH terms

Animals
CpG Islands / immunology*
Epigenesis, Genetic*
Female
Humans
Macrophages, Peritoneal / immunology*
Male
Methyl-CpG-Binding Protein 2 / immunology*
Microglia / immunology*
Rett Syndrome / immunology*

Substances

Methyl-CpG-Binding Protein 2