Comparison of the in vitro activities of newer triazoles and established antifungal agents against Trichophyton rubrum

Shuwen Deng; Chao Zhang; Seyedmojtaba Seyedmousavi; Shuang Zhu; Xin Tan; Yiyang Wen; Xin Huang; Wenzhi Lei; Zhaojing Zhou; Wenjie Fang; Shuaishuai Shen; Danqi Deng; Weihua Pan; Wanqing Liao

doi:10.1128/AAC.00244-15

Comparison of the in vitro activities of newer triazoles and established antifungal agents against Trichophyton rubrum

Antimicrob Agents Chemother. 2015 Jul;59(7):4312-4. doi: 10.1128/AAC.00244-15. Epub 2015 Apr 20.

Authors

Shuwen Deng¹, Chao Zhang¹, Seyedmojtaba Seyedmousavi², Shuang Zhu¹, Xin Tan³, Yiyang Wen⁴, Xin Huang⁴, Wenzhi Lei⁴, Zhaojing Zhou¹, Wenjie Fang¹, Shuaishuai Shen⁴, Danqi Deng³, Weihua Pan⁵, Wanqing Liao⁵

Affiliations

¹ Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
² Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands Invasive Fungi Research Center, Mazandaran University Medical Center, Sari, Iran.
³ Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
⁴ Department of Dermatology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
⁵ Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China panweihua@medmail.com.cn liaowanqing@sohu.com.

Abstract

One hundred eleven clinical Trichophyton rubrum isolates were tested against 7 antifungal agents. The geometric mean MICs of all isolates were, in increasing order: terbinafine, 0.03 mg/liter; voriconazole, 0.05 mg/liter; posaconazole, 0.11 mg/liter; isavuconazole, 0.13 mg/liter; itraconazole, 0.26 mg/liter; griseofulvin, 1.65 mg/liter; and fluconazole, 2.12 mg/liter.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Humans
Microbial Sensitivity Tests
Tinea / drug therapy
Tinea / microbiology
Triazoles / pharmacology*
Trichophyton / drug effects*

Substances

Antifungal Agents
Triazoles