Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Yi-Han Hsieh; Kuang-Kai Liu; Rohidas S Sulake; Jui-I Chao; Chinpiao Chen

doi:10.1016/j.bmcl.2015.03.089

Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Bioorg Med Chem Lett. 2015;25(10):2074-7. doi: 10.1016/j.bmcl.2015.03.089. Epub 2015 Apr 4.

Authors

Yi-Han Hsieh¹, Kuang-Kai Liu², Rohidas S Sulake¹, Jui-I Chao³, Chinpiao Chen⁴

Affiliations

¹ Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan.
² Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan.
³ Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan. Electronic address: jichao@faculty.nctu.edu.tw.
⁴ Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan. Electronic address: chinpiao@mail.ndhu.edu.tw.

PMID: 25890802
DOI: 10.1016/j.bmcl.2015.03.089

Abstract

Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

Keywords: Deaggregation; Lung cancer; Microwave irradiating; Nanodiamond; Paclitaxel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Diamond*
Microwaves*
Nanostructures*
Paclitaxel / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Diamond
Paclitaxel