The mitochondrial unselective channel in Saccharomyces cerevisiae

Manuel Gutiérrez-Aguilar; Salvador Uribe-Carvajal

doi:10.1016/j.mito.2015.04.002

The mitochondrial unselective channel in Saccharomyces cerevisiae

Mitochondrion. 2015 May:22:85-90. doi: 10.1016/j.mito.2015.04.002. Epub 2015 Apr 16.

Authors

Manuel Gutiérrez-Aguilar¹, Salvador Uribe-Carvajal²

Affiliations

¹ Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA. Electronic address: manu@unam.mx.
² Molecular Genetics Department, Instituto de Fisiología Celular, UNAM, Mexico City, Mexico.

PMID: 25889953
DOI: 10.1016/j.mito.2015.04.002

Abstract

Opening of the mitochondrial permeability transition (MPT) pore mediates the increase in the unselective permeability to ions and small molecules across the inner mitochondrial membrane. MPT results from the opening of channels of unknown identity in mitochondria from plants, animals and yeast. However, the effectors and conditions required for MPT to occur in different species are remarkably disparate. Here we critically review previous and recent findings concerning the mitochondrial unselective channel of the yeast Saccharomyces cerevisiae to determine if it can be considered a counterpart of the mammalian MPT pore.

Keywords: Bioenergetics; Cell death; Mitochondrial evolution; Mitochondrial unselective channel; Permeability transition pore; Yeast mitochondria.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Ion Channels / metabolism*
Mitochondrial Membrane Transport Proteins / metabolism*
Mitochondrial Membranes / enzymology*
Mitochondrial Membranes / metabolism*
Mitochondrial Permeability Transition Pore
Saccharomyces cerevisiae / enzymology*
Saccharomyces cerevisiae / metabolism*

Substances

Ion Channels
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore