Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers: Recent Progress

Chen Xu; Hamed Vavadi; Alex Merkulov; Hai Li; Mohsen Erfanzadeh; Atahar Mostafa; Yanping Gong; Hassan Salehi; Susan Tannenbaum; Quing Zhu

doi:10.1177/0161734615580280

Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers: Recent Progress

Ultrason Imaging. 2016 Jan;38(1):5-18. doi: 10.1177/0161734615580280. Epub 2015 Apr 16.

Authors

Chen Xu¹, Hamed Vavadi², Alex Merkulov³, Hai Li⁴, Mohsen Erfanzadeh², Atahar Mostafa⁴, Yanping Gong⁴, Hassan Salehi⁴, Susan Tannenbaum³, Quing Zhu⁵

Affiliations

¹ Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
² Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
³ University of Connecticut Health Center, Farmington, CT, USA.
⁴ Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA.
⁵ Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA zhu@engr.uconn.edu.

Abstract

In this manuscript, we review the current progress of utilizing ultrasound-guided diffuse optical tomography (US-guided DOT) for predicting and monitoring neoadjuvant chemotherapy (NAC) outcomes of breast cancer patients. We also report the recent advance on optical tomography systems toward portable and robust clinical use at multiple clinical sites. The first patient who has been closely monitored before NAC, at day 2, day 8, end of first three cycles of NAC, and before surgery is given as an example to demonstrate the potential of US-guided DOT technique.

Keywords: breast cancer treatment monitoring; dual-modalities; near infrared imaging; ultrasound; ultrasound-guided optical imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Breast Neoplasms / diagnosis*
Breast Neoplasms / diagnostic imaging
Breast Neoplasms / drug therapy*
Chemotherapy, Adjuvant
Female
Humans
Neoadjuvant Therapy*
Tomography, Optical / methods*
Treatment Outcome
Ultrasonography, Mammary / methods*

Grants and funding

R01 EB002136/EB/NIBIB NIH HHS/United States