Life after MOMP

Vivian Gama; Mohanish Deshmukh

doi:10.1016/j.molcel.2015.03.035

Life after MOMP

Mol Cell. 2015 Apr 16;58(2):199-201. doi: 10.1016/j.molcel.2015.03.035.

Authors

Vivian Gama¹, Mohanish Deshmukh²

Affiliations

¹ Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
² Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohanish@med.unc.edu.

Abstract

In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation.

Publication types

Comment

MeSH terms

Animals
Apoptosis / physiology*
DNA Damage*
Genomic Instability*
Humans
Mitochondrial Membranes / physiology*

Abstract

Publication types

MeSH terms

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