[The level of expression of molecules of adhesion on monocytes depending on morphological differentiation of nuclei]

Klin Lab Diagn. 2014 Oct;59(10):21-2.
[Article in Russian]

Abstract

The article demonstrates that in conditions of absence of antigen stimulation in venous blood percentage of promocytes made up 26% (20.0; 36.0), monocytes proper--40% (29.5; 47.0), polymorphic nuclear monocytes--31.0% (24.5; 43.0). The molecule of L-selectin was expressed by 42.2% of monocytes; of LFA-1--99.72%; of ICAM-1--88.88%; of LFA-3--94.11%; of PECAM-1--97.50% of monocytes. The positive correlation is established between content of polymorphic nuclear monocytes and level of expression of molecules of LFA-1, ICAM-1, LFA-3, and PECAM-1. This occurrence can testify readiness to implementation of phase of sliding, solid adhesion and transmigration immediately by polymorphic nuclear monocytes primarily.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Cell Adhesion Molecules / biosynthesis*
  • Cell Differentiation / physiology*
  • Cell Nucleus / metabolism*
  • Female
  • Gene Expression Regulation / physiology*
  • Humans
  • Male
  • Middle Aged
  • Monocytes / cytology
  • Monocytes / metabolism*

Substances

  • Cell Adhesion Molecules