Stability analysis of a model of atherosclerotic plaque growth

Comput Math Methods Med. 2015:2015:164035. doi: 10.1155/2015/164035. Epub 2015 Mar 25.

Abstract

Atherosclerosis, the formation of life-threatening plaques in blood vessels, is a form of cardiovascular disease. In this paper, we analyze a simplified model of plaque growth to derive physically meaningful results about the growth of plaques. In particular, the main results of this paper are two conditions, which express that the immune response increases as LDL cholesterol levels increase and that diffusion prevails over inflammation in a healthy artery.

MeSH terms

  • Algorithms
  • Arteries / pathology
  • Atherosclerosis / physiopathology*
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / immunology
  • Computer Simulation
  • Humans
  • Inflammation / pathology
  • Macrophages / metabolism
  • Medical Informatics / methods
  • Models, Theoretical
  • Phagocytosis
  • Plaque, Atherosclerotic / diagnosis
  • Plaque, Atherosclerotic / physiopathology*

Substances

  • Cholesterol, LDL