Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

M Inglese; N Oesingmann; W Zaaraoui; J P Ranjeva; L Fleysher

doi:10.1016/j.msard.2013.03.009

Sodium imaging as a marker of tissue injury in patients with multiple sclerosis

Mult Scler Relat Disord. 2013 Oct;2(4):263-9. doi: 10.1016/j.msard.2013.03.009. Epub 2013 May 3.

Authors

M Inglese¹, N Oesingmann², W Zaaraoui³, J P Ranjeva³, L Fleysher⁴

Affiliations

¹ Department of Neurology, Mount Sinai School of Medicine, NY, USA; Department of Radiology, Mount Sinai School of Medicine, NY, USA; Department of Neuroscience, Mount Sinai School of Medicine, NY, USA. Electronic address: matilde.inglese@mssm.edu.
² Siemens Medical Solutions USA, Inc., New York University, NY, USA.
³ CRMBM-CEMEREM, UMR 7339, CNRS, Aix-Marseille université, France; Siemens Medical Solutions USA, Inc., New York University, NY, USA.
⁴ Department of Radiology, Mount Sinai School of Medicine, NY, USA.

PMID: 25877838
DOI: 10.1016/j.msard.2013.03.009

Abstract

Recent studies have suggested that intra-axonal sodium accumulation contribute to axonal degeneration in patients with MS. Advances in MRI hardware and software allow acquisition of brain sodium signal in vivo. This review begins with a summary of the experimental evidence for impairment of sodium homeostasis in MS. Then, MRI methods for sodium acquisition are reviewed and the application of the techniques in patients with MS is discussed. Sodium imaging and ultra-high field MRI have the potential to provide tissue-specific markers of neurodegeneration in MS.

Keywords: Multiple Sclerosis; Multiple-quantum filtering; Sodium imaging; Ultra-high magnetic field.

Publication types

Review