Acute disseminated encephalomyelitis associated with positive voltage gated potassium channel complex antibody

Marios Kaliakatsos; Yael Hacohen; Ata Siddiqui; Nomazulu Dlamini; Angela Vincent; Ming Lim

doi:10.1016/j.msard.2012.09.007

Acute disseminated encephalomyelitis associated with positive voltage gated potassium channel complex antibody

Mult Scler Relat Disord. 2013 Apr;2(2):147-50. doi: 10.1016/j.msard.2012.09.007. Epub 2012 Oct 24.

Authors

Marios Kaliakatsos¹, Yael Hacohen², Ata Siddiqui³, Nomazulu Dlamini¹, Angela Vincent², Ming Lim⁴

Affiliations

¹ Paediatric Neurosciences, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK.
² Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
³ Department of Radiology, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK.
⁴ Paediatric Neurosciences, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: Ming.lim@gstt.nhs.uk.

PMID: 25877636
DOI: 10.1016/j.msard.2012.09.007

Abstract

Voltage gated potassium channel (VGKC) complex antibodies are associated with encephalopathies both in adult and children. The incidence of antibodies in the central nervous system demyelinating disorders is increasingly reported although their direct pathogenic role remains to be evaluated, with the exception of Aquaporin 4 antibodies. Here we describe a case of a 28 month old boy presenting with acute disseminated encephalomyelitis, with positive VGKC-complex antibodies and low sodium levels. He was treated with steroids and made a clinical and radiological recovery with normalisation of antibody levels.

Keywords: Acute demyelination syndrome; Acute disseminated encephalomyelitis; Autoantibodies; Brainstem demyelination; Brainstem encephalitis; Voltage gated potassium channel complex antibodies.