Objective: To evaluate the changes of carotid adventitial thickness (AT) and intima media thickness (IMT) and their relationship in metabolic syndrome (MS) patients using high-frequency ultrasound.
Methods: The values of mean AT and mean IMT were measured and calculated for 161 MS patients and compared them with 94 age and gender-matched controls as determined by high-frequency ultrasound between 2009-2011. And 161 patients were divided further into 2 groups of MS with plaque (MS-P, n = 70) and MS without plaque (MS-NP, n = 91).
Results: MS-P and MS-NP patients had significantly higher values of mean IMT and carotid artery wall thickness than controls and MS-P patients had significantly higher values of mean AT than controls ((0.77 ± 0.13) mm vs (0.66 ± 0.11) mm, P < 0.01). Moreover, MS-P patients had significantly higher values of mean IMT ((0.98 ± 0.20) mm vs (0.76 ± 0.10) mm, P < 0.01), mean AT ((0.77 ± 0.13) vs (0.69 ± 0.13) mm, P < 0.01) and carotid artery wall thickness ((1.61 ± 0.16)mm vs (1.42 ± 0.09) mm, P = 0.002) than MS-NP patients. And mean AT was positively correlated with mean IMT in controls,MS-P and MS-NP patients (r = 0.603, P < 0.01, r = 0.325, P = 0.005 and r = 0.344, P = 0.004 separately).
Conclusion: For IMT and AT in MS patients with and without plaques, adventitia participates in vascular remodeling and may be distinguished by high-frequency ultrasound.