Co-existence of neurofibromatosis type 2 and multiple sclerosis: A case report

Hoda Naghshineh; Daryoush Shahin; Mohammad Ali Sahraian; Alireza Minagar

doi:10.1016/j.msard.2013.08.008

Co-existence of neurofibromatosis type 2 and multiple sclerosis: A case report

Mult Scler Relat Disord. 2014 May;3(3):384-6. doi: 10.1016/j.msard.2013.08.008. Epub 2013 Nov 7.

Authors

Hoda Naghshineh¹, Daryoush Shahin¹, Mohammad Ali Sahraian², Alireza Minagar³

Affiliations

¹ Sina MS Research Center, Institute of Neuroscience, Tehran University of Medical Sciences, Sina Hospital, Hasan abad Square, Tehran, Iran.
² Sina MS Research Center, Institute of Neuroscience, Tehran University of Medical Sciences, Sina Hospital, Hasan abad Square, Tehran, Iran. Electronic address: msahrai@sina.tums.ac.ir.
³ Department of Neurology, LSU Health Sciences Center, Shreveport, LA 71130 USA.

PMID: 25876477
DOI: 10.1016/j.msard.2013.08.008

Abstract

Neurofibromatosis type 2 (NF-2) is an autosomal-dominant neurogenetic disorder which is characterized by the development of multiple tumors such as schwannomas, meningiomas and ependymomas. The responsible gene for NF-2 is located on chromosome 22q12. We present a 42-year-old male who developed multiple sclerosis 5 years after diagnosis of NF2 and radiosurgery for bilateral schwannomas.

Keywords: Demyelinating disease; Gamma knife best; Multiple sclerosis; Neurofibromatosis; Radiofrequency surgery; Vestibular schawannoma.