Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

J Pathol. 2015 Aug;236(4):403-6. doi: 10.1002/path.4544. Epub 2015 May 7.

Abstract

Published recently in the Journal of Pathology, Lavoz et al. show that Gremlin promotes renal inflammation directly via VEGFR2. As Gremlin has been implicated in many other diseases, such as heart, lung and liver fibrosis, osteogenesis, angiogenesis and cancer, the new findings provide a rationale for novel concepts to investigate and potentially treat several pathologies.

Keywords: Gremlin; VEGFR2; cancer; fibrosis; renal inflammation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cytokines
  • Female
  • Humans
  • Inflammation Mediators / metabolism*
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Kidney / metabolism*
  • Male
  • Nephritis / metabolism*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism*

Substances

  • Cktsf1b1 protein, mouse
  • Cytokines
  • GREM1 protein, human
  • Inflammation Mediators
  • Intercellular Signaling Peptides and Proteins
  • KDR protein, human
  • Kdr protein, mouse
  • Vascular Endothelial Growth Factor Receptor-2