Abstract
A highly diastereoselective annulation of simple aldehydes and 5-alkenyl thiazolones, via oxidative NHC catalysis has been developed. This strategy provides facile access to a diverse library of functionalized chiral thiazolo pyrones. Aerobic oxygen can also be applied as a secondary oxidant to avoid the use of stoichiometric organic or inorganic oxidants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Catalysis
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Heterocyclic Compounds / chemistry*
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Oxidation-Reduction
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Stereoisomerism
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Thiazoles / chemistry*
Substances
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Aldehydes
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Heterocyclic Compounds
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Pyrones
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Thiazoles
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carbene
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Methane