Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome

Kenan Barut; Turkay Rzayev; Nur Canpolat; Yasemin Ozluk; Ilknur Tugal-Tutkun; Ozgur Kasapcopur

doi:10.1186/s12348-015-0035-2

Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome

J Ophthalmic Inflamm Infect. 2015 Feb 13:5:3. doi: 10.1186/s12348-015-0035-2. eCollection 2015.

Authors

Kenan Barut¹, Turkay Rzayev¹, Nur Canpolat², Yasemin Ozluk³, Ilknur Tugal-Tutkun⁴, Ozgur Kasapcopur¹

Affiliations

¹ Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
² Department of Pediatric Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
³ Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
⁴ Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093 Istanbul, Turkey.

Abstract

Background: Tubulointerstitial nephritis and uveitis [TINU] syndrome is a rare disorder that may also be underdiagnosed. Patients with TINU syndrome typically present with an acute bilateral nongranulomatous anterior uveitis following symptoms of systemic illness.

Findings: We report the case of a 15-year-old girl who presented with acute granulomatous iridocyclitis and was diagnosed with TINU syndrome based on renal biopsy findings. Both her uveitis and interstitial nephritis promptly responded to high-dose corticosteroid treatment, and there were no relapses during follow-up of 20 months.

Conclusions: TINU should be included in the differential diagnosis of patients who present with acute granulomatous uveitis.

Keywords: Granulomatous iridocyclitis; TINU syndrome; Tubulointerstitial nephritis; Uveitis.