Recent Progress towards Transition-Metal-Catalyzed Synthesis of Fluorenes

Ai-Hua Zhou; Fei Pan; Chunyin Zhu; Long-Wu Ye

doi:10.1002/chem.201500545

Recent Progress towards Transition-Metal-Catalyzed Synthesis of Fluorenes

Chemistry. 2015 Jul 13;21(29):10278-88. doi: 10.1002/chem.201500545. Epub 2015 Apr 9.

Authors

Ai-Hua Zhou¹, Fei Pan¹, Chunyin Zhu², Long-Wu Ye^{3

4}

Affiliations

¹ State Key Laboratory for Physical Chemistry of Solid Surfaces and The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, Fujian (P. R. China).
² School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013 (P. R. China). zhucycn@gmail.com.
³ State Key Laboratory for Physical Chemistry of Solid Surfaces and The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, Fujian (P. R. China). longwuye@xmu.edu.cn.
⁴ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (P. R. China). longwuye@xmu.edu.cn.

PMID: 25858775
DOI: 10.1002/chem.201500545

Abstract

Fluorenes are a commonly encountered structural motif in materials science, pharmaceutical chemistry, and organic synthesis. Among various strategies towards the synthesis of this unique structure, transition metal-catalyzed functionalization has emerged as one of the most efficient methods. This Minireview presents an overview of the recent advances in this emerging area by highlighting the reactions' specificity and applicability and, where possible, provides a mechanistic rationale.

Keywords: CH activation; fluorenes; homogeneous catalysis; polycyclic aromatic hydrocarbons; transition metals.