Formation of spherical and core-shell polymeric microparticles from glycopolymers

Carbohydr Polym. 2015 Jul 10:125:281-7. doi: 10.1016/j.carbpol.2015.02.052. Epub 2015 Mar 5.

Abstract

6-O-methacryloyl-α-d-glucoside 2 and 4-bromophenyl-6-O-methacryloyl-d-glucothioside 7, obtained by enzyme-catalyzed synthesis, have been homo-polymerized and copolymerized with styrene by a free radical process, yielding polymer materials with sugar moieties, attached to the polymer backbone via ester linkages. The results demonstrated that modifying the structural features of the monomers greatly affected the thermal and rheological properties of the polymers. The polymer materials obtained have been characterized by NMR, MALDI-MS, DSC, AFM, and EWC (equilibrium water content). The AFM images indicated the formation of spherical and core-shell polymeric microparticles.

Keywords: Carbohydrate chemistry; Free radical copolymerization; Glycopolymers; Polymeric microparticles; Vinyl glucose monomers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Glucosides / chemical synthesis*
  • Glucosides / chemistry
  • Nanoparticles / chemistry*
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Polymethacrylic Acids / chemical synthesis*
  • Polymethacrylic Acids / chemistry

Substances

  • Glucosides
  • Polymers
  • Polymethacrylic Acids