Objective: To investigate the correlation between serum levels of follicle-stimulating hormone (FSH) and total procollagen I N-terminal propeptide (TP1NP) in perimenopausal women.
Methods: Total 274 women aged 33~60 y with perimenopausal period were enrolled in this study. Serum levels of FSH and TP1NP were detected by electrochemiluminescence.
Results: In 274 perimenopausal women, the average level of TP1NP was (48.99±20.31) ng/mL, which was positively correlated with FSH level (r=0.159, P=0.009). In 40-50 age group, TP1NP level in women with FSH<40 mIU/mL was lower than that in those with FSH≥40mIU/mL [(35.05±18.11) ng/mL vs (51.33±24.67) ng/mL; t=-2.954, P=0.004]. However, in <40 and 50-60 age groups, there were no significant differences in TP1NP levels between patients with FSH<40 mIU/mL and those with FSH≥40 mIU/mL (t=-0.063, P=0.950; t=1.177, P=0.242). Multiple linear regression analysis showed that standardized coefficients of age variable was 0.047 (P=0.448) and standardized coefficients of FSH variable was 0.146 (P=0.019).
Conclusion: TP1NP levels showed a certain correlation with FSH in perimenopausal women, especially for women aged 40-50, indicating that high FSH levels may be important factors for osteoporosis in postmenopausal women.
目的: 探讨围绝经期妇女血清中促卵泡激素（FSH）水平与骨代谢指标总Ⅰ型前胶原氨基端延长肽（TP1NP）的相关性。
方法: 选取2011年8月—2012年11月在浙江大学医学院附属妇产科医院就诊的围绝经期妇女274例，年龄33~60岁。应用电化学发光法检测妇女血清FSH和TP1NP水平，并应用多重线性回归模型分析围绝经期妇女的年龄、FSH及TP1NP因素间的相关性。
结果: 274例围绝经期妇女的TP1NP平均水平为（48.99±20.31）ng/mL，且FSH水平与TP1NP水平呈正相关（ r=0.159， P=0.009）。在40~50岁妇女中，FSH水平 < 40 mIU/mL者的TP1NP水平低于FSH>40 mIU/mL者[（35.05±18.11）ng/mL与（51.33±24.67）ng/mL; t=－2.954， P=0.004]；而在小于40岁和51~60岁妇女中，不同FSH水平下TP1NP水平差异无统计学意义（ t=－0.063， P=0.950； t=1.177， P=0.242）。多重线性回归模型分析显示年龄变量标准化偏回归系数为0.047（ P=0.448），而FSH变量标准化偏回归系数为0.146（ P=0.019），可见FSH水平比年龄变量对TP1NP的影响更大。
结论: 围绝经期妇女TP1NP水平与FSH呈现一定相关性，尤其是对于40~50岁的妇女，高FSH可能是引起绝经后骨质疏松的重要因素。