This study is an attempt to investigate validity and reliability of the Persian version of Death Depression Scale among male and female nurses at Jundishapur University of Medical Science and 2 private hospitals in Ahvaz, Iran, who were selected by a convenience sampling method after obtaining informed consent. They completed the Death Depression Scale-Revised (DDS-R), Death Anxiety Scale, Death Obsession Scale, as well as Short-Form of Beck Depression Questionnaire (BDI-13). The results of exploratory factor analysis on DDS-R identified 3 factors. Cronbach's alpha coefficient was 0.93 for the entire measure (19 items), with alphas ranging from .80 to .94 for the individual factors. Indices of concurrent validity for this scale with Death Anxiety, Death Obsession Scales, and BDI-13 were all significant (p < 0.001). Given the validity and reliability of the DDS-R, this scale can be used in clinical settings and research studies.