SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations

Biosci Biotechnol Biochem. 2015;79(9):1481-3. doi: 10.1080/09168451.2015.1031077. Epub 2015 Apr 7.

Abstract

Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.

Keywords: EBP2; SMY2; SYH1; ribosome biogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / genetics*
  • Mutation
  • RNA, Ribosomal / genetics
  • Ribosomal Proteins
  • Ribosome Subunits, Large, Eukaryotic / genetics
  • Ribosomes / genetics*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae Proteins / genetics*
  • Vesicular Transport Proteins / genetics*

Substances

  • Carrier Proteins
  • EBP2 protein, S cerevisiae
  • RNA, Ribosomal
  • Ribosomal Proteins
  • SMY2 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Vesicular Transport Proteins