Angiotensins as therapeutic targets beyond heart disease

Danielle Gomes Passos-Silva; Enrique Brandan; Robson Augusto Souza Santos

doi:10.1016/j.tips.2015.03.001

Angiotensins as therapeutic targets beyond heart disease

Trends Pharmacol Sci. 2015 May;36(5):310-20. doi: 10.1016/j.tips.2015.03.001. Epub 2015 Apr 3.

Authors

Danielle Gomes Passos-Silva¹, Enrique Brandan², Robson Augusto Souza Santos³

Affiliations

¹ National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
² Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
³ National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, 395 Avenida Princesa Isabel, Porto Alegre, Rio Grande do Sul, 90620-001, Brazil. Electronic address: robsonsant@gmail.com.

PMID: 25847571
DOI: 10.1016/j.tips.2015.03.001

Abstract

The renin-angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating hypertension and related cardiovascular diseases is well established. However, actions of the RAS go far beyond the targets initially described. In this regard, the recent identification of novel components of the RAS, including angiotensin-(1-7) [Ang-(1-7)], Ang-(1-9), and alamandine, have opened new possibilities for interfering with the development and manifestations of cardiovascular and non-cardiovascular diseases. In this article, we briefly review novel targets for angiotensins and its therapeutic implications in diverse areas, including cancer, inflammation, and glaucoma.

Keywords: Mas receptor; angiotensin II; angiotensin-(1–7); cancer; renin–angiotensin system.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiotensin-Converting Enzyme Inhibitors / pharmacology
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Animals
Erectile Dysfunction / drug therapy*
Erectile Dysfunction / metabolism
Glaucoma / drug therapy*
Glaucoma / metabolism
Heart Diseases / drug therapy*
Heart Diseases / metabolism
Humans
Liver Cirrhosis / drug therapy*
Liver Cirrhosis / metabolism
Male
Pulmonary Fibrosis / drug therapy*
Pulmonary Fibrosis / metabolism
Renin-Angiotensin System*

Substances

Angiotensin-Converting Enzyme Inhibitors