Planar cell polarity, the polarization of cells within the plane of the epithelium, orthogonal to the apical-basal axis, is essential for a growing list of developmental events, and - over the last 15 years - has evolved from a little-studied curiosity in Drosophila to the subject of a substantial research enterprise. In that time, it has been recognized that two molecular systems are responsible for polarization of most tissues: Both the "core" Frizzled system and the "global" Fat/Dachsous/Four-jointed system produce molecular asymmetry within cells, and contribute to morphological polarization. In this review, we discuss recent findings on the molecular mechanism that links "global" directional signals with local coordinated polarity.
Keywords: DWnt4; Dachsous; Fat; Prickle; microtubules; planar cell polarity.
© 2015 WILEY Periodicals, Inc.