γHV68 vGAT: a viral pseudoenzyme pimping for PAMPs

Daniel Kolakofsky; Dominique Garcin

doi:10.1016/j.molcel.2015.03.021

γHV68 vGAT: a viral pseudoenzyme pimping for PAMPs

Mol Cell. 2015 Apr 2;58(1):3-4. doi: 10.1016/j.molcel.2015.03.021.

Authors

Daniel Kolakofsky¹, Dominique Garcin²

Affiliations

¹ Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland.
² Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland. Electronic address: dominique.garcin@unige.ch.

PMID: 25839430
DOI: 10.1016/j.molcel.2015.03.021

Abstract

In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses.

Publication types

Comment

MeSH terms

Animals
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor / immunology*
DEAD Box Protein 58
DEAD-box RNA Helicases / immunology*
Gammaherpesvirinae / immunology*
Humans
Immune Evasion / genetics*
RNA, Viral / immunology*
Receptors, Immunologic
Viral Proteins / immunology*

Substances

RNA, Viral
Receptors, Immunologic
Viral Proteins
RIGI protein, human
DEAD Box Protein 58
DEAD-box RNA Helicases
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
phosphoribosylformylglycinamidine synthetase