A practical guide to the diagnosis, treatment, and prevention of neonatal infections

Pediatr Clin North Am. 2015 Apr;62(2):491-508. doi: 10.1016/j.pcl.2014.11.010.

Abstract

Neonatal infections continue to cause morbidity and mortality in infants. Among approximately 400,000 infants followed nationally, the incidence rates of early-onset sepsis infection within 3 days of life are 0.98 cases per 1000 live births. Newborn infants are at increased risk for infections because they have relative immunodeficiency. This article provides evidence-based practical approaches to the diagnosis, management, and prevention of neonatal infections.

Keywords: Antibacterial therapy; Antiviral therapy; Early-onset sepsis; Late-onset sepsis; Neonatal antimicrobial stewardship; Neonatal infections; Newborn sepsis; Respiratory viral infections in infants.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • Bacterial Infections / diagnosis*
  • Bacterial Infections / prevention & control
  • Bacterial Infections / therapy*
  • Bacterial Infections / transmission
  • Ganciclovir / analogs & derivatives
  • Ganciclovir / therapeutic use
  • Humans
  • Hygiene
  • Infant, Newborn
  • Mycoses / diagnosis*
  • Mycoses / prevention & control
  • Mycoses / therapy*
  • Mycoses / transmission
  • Prebiotics
  • Probiotics / therapeutic use
  • Sepsis / diagnosis
  • Sepsis / therapy
  • Valganciclovir
  • Virus Diseases / diagnosis*
  • Virus Diseases / prevention & control
  • Virus Diseases / therapy*
  • Virus Diseases / transmission

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antiviral Agents
  • Prebiotics
  • Valganciclovir
  • Ganciclovir