Aberrant brain activation of error processing among adults with attention deficit and hyperactivity disorder

Chiao-Yun Chen; Ju-Yu Yen; Cheng-Fang Yen; Cheng-Sheng Chen; Gin-Chung Liu; Chih-Yuan Liang; Chih-Hung Ko

doi:10.1016/j.kjms.2015.01.001

Aberrant brain activation of error processing among adults with attention deficit and hyperactivity disorder

Kaohsiung J Med Sci. 2015 Apr;31(4):179-87. doi: 10.1016/j.kjms.2015.01.001. Epub 2015 Feb 3.

Authors

Chiao-Yun Chen¹, Ju-Yu Yen², Cheng-Fang Yen³, Cheng-Sheng Chen³, Gin-Chung Liu¹, Chih-Yuan Liang⁴, Chih-Hung Ko⁵

Affiliations

¹ Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
² Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
³ Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁴ Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁵ Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: chihhungko@gmail.com.

PMID: 25835273
DOI: 10.1016/j.kjms.2015.01.001

Abstract

Individuals with adult attention deficit/hyperactivity disorder (ADHD) have a deficit in their cognitive control. The aim of this study was to reveal the brain correlates of the deficits in response inhibition or error processing in adult ADHD. A total of 29 adults with ADHD and 25 control individuals were recruited. They completed an event-related-design Go/No-go task under functional magnetic resonance imaging scanning. Both the ADHD group and the control group exhibited activation of the frontostriatal network when processing response inhibition. They also exhibited activation of the frontoinsula cortex and anterior cingulate in error processing. Adults with ADHD have a lower brain activation of error processing over the right inferior frontal lobe adjacent to the insula than control individuals. The altered frontoinsula cortex activation may represent the mechanism of error processing deficit among adults with ADHD.

Keywords: ADHD; Error processing; Inferior frontal lobe; Insula; Response inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Attention Deficit Disorder with Hyperactivity / physiopathology*
Brain / physiopathology*
Brain Mapping
Female
Frontal Lobe / physiopathology
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Young Adult