Simplified process for preparation of schizophyllan solutions for biomaterial applications

Prep Biochem Biotechnol. 2016;46(3):313-9. doi: 10.1080/10826068.2015.1031392.

Abstract

Schizophyllan is a biopolymer commercially produced for pharmaceutical and cosmetics uses. However, schizophyllan also has potential biomaterial applications. Schizophyllan is conventionally produced from glucose and recovered by diafiltration and ultrafiltration to produce a highly purified product. Here we demonstrate a simplified process for preparation of schizophyllan solutions for biomaterial applications. Schizophyllan was produced in 1.5-L bioreactors from distiller's dried grains with solubles (DDGS), an abundant coproduct of dry grind fuel ethanol production. Downstream processing eliminated filtration and concentration steps, providing solutions containing 4.2 ± 0.3 g schizophyllan/L. Solutions contained high-molecular-weight schizophyllan and exhibited viscosity properties similar to those of commercial schizophyllan. Schizophyllan solutions showed promise as a component of biolubricants in friction and wear tests and by dynamic surface and interfacial tension measurements.

Keywords: Coefficient of friction; distiller’s dried grains with solubles; downstream processing; schizophyllan; surface tension; viscosity.

MeSH terms

  • Biocompatible Materials*
  • Bioreactors
  • Sizofiran / chemistry*

Substances

  • Biocompatible Materials
  • Sizofiran