Abstract
Previous studies reported a relatively low prevalence of transmitted drug resistance (TDR) in South Korea (<5%). A genotypic resistance test was performed on 131 treatment-naive HIV-1-infected individuals from February 2013 to February 2014. Eleven individuals (8.4%) presented TDR, of whom eight had K103N, revealing a significant increase in K103N TDR compared to previous studies (p<0.001). Using phylogenetic analysis, we identified three distinct clustering pairs with genetic relativeness and a total of five independent strains among the eight K103N cases. Our findings suggest that multiple sources of K103N occurred, most likely as a consequence of increased efavirenz use in South Korea.
MeSH terms
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Adult
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Alkynes
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / therapeutic use*
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Benzoxazines / pharmacology
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Benzoxazines / therapeutic use*
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Cluster Analysis
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Cyclopropanes
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Drug Resistance, Viral*
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Genotype
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HIV Infections / epidemiology
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HIV Infections / transmission
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HIV Infections / virology*
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HIV Reverse Transcriptase / genetics*
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HIV-1 / drug effects*
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HIV-1 / enzymology
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HIV-1 / genetics
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HIV-1 / isolation & purification
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Humans
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Incidence
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Male
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Molecular Sequence Data
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Mutation, Missense*
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Phylogeny
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Republic of Korea / epidemiology
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Sequence Analysis, DNA
Substances
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Alkynes
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Anti-HIV Agents
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Benzoxazines
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Cyclopropanes
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase
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efavirenz