Abstract
We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzothiazoles / chemistry
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Biocatalysis
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Biosensing Techniques
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DNA, Catalytic / chemistry*
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DNA, Catalytic / metabolism*
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DNA-Directed DNA Polymerase / metabolism*
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G-Quadruplexes*
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Models, Molecular
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Nucleotides / metabolism*
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Oxidation-Reduction
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Polymorphism, Single Nucleotide
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Sulfonic Acids / chemistry
Substances
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Benzothiazoles
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DNA, Catalytic
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Nucleotides
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Sulfonic Acids
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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DNA-Directed DNA Polymerase